Testing the angiogenic potential of cerebrovascular malformation by use of a rat cornea model: Usefulness and novel assessment of change over time


Konya D., Yildirim O., Kurtkaya O., Kilic K., Black P., Pamir M., ...Daha Fazla

NEUROSURGERY, cilt.56, sa.6, ss.1339-1345, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1227/01.neu.0000159886.08629.b7
  • Dergi Adı: NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1339-1345
  • Anahtar Kelimeler: angiogenesis, arteriovenous malformation, brain, cavernous malformation, cerebrovascular malformations, corneal angiogenesis model, vasculogenesis, venous angioma, CEREBRAL ARTERIOVENOUS-MALFORMATIONS, ENDOTHELIAL GROWTH-FACTOR, CENTRAL-NERVOUS-SYSTEM, CAVERNOUS MALFORMATION, STRUCTURAL PROTEINS, TUMOR ANGIOGENESIS, MOUSE CORNEA, EXPRESSION, INHIBITION, MECHANISMS
  • Marmara Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: This experimental study assessed the usefulness of a rat model of corneal angiogenesis for assessing the angiogenic activity of cerebrovascular malformations (CVMs) over time. It is the first investigation to have focused on dynamic quantification of angiogenesis related to CVMs (i.e., assessing changes over time as opposed to one point in time) and the first to have compared different CVMs and other tissues in this way.