Somatostatin infusion withdrawal in the diagnosis of childhood growth hormone deficiency

Bosnak M., Dikici B., Haspolat K., Dogru Ö. , Ozkan I., Ece A.

PEDIATRICS INTERNATIONAL, cilt.45, sa.5, ss.538-542, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Konu: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1046/j.1442-200x.2003.01774.x
  • Sayfa Sayıları: ss.538-542


Objective: An evaluation of growth hormone (GH) testing for GH deficiency (GHD) in childhood is confounded by the lack of a world-wide consensus on the definition of GHD. Although a single GH test remains the most powerful biochemical tool in the evaluation of a child with growth failure, the test remains far from ideal. Withdrawal of somatostatin (SS) infusion is followed by a rebound rise of GH thought to be mediated by endogenous GH-releasing hormone (GHRH) function. This study was designed to compare the GH response to 90 min SS infusion in children with normal GH secretion versus children with GH deficiency.