Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

Kaya Z., Caglayan S., Akkiprik M., Aral C., Ozisik G., Ozata M., ...Daha Fazla

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.39, sa.5, ss.557-566, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s40618-015-0409-1
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.557-566
  • Anahtar Kelimeler: Metabolic syndrome, Glucocorticoid receptor gene, Glucocorticoid, C-REACTIVE PROTEIN, FRAGMENT-LENGTH-POLYMORPHISM, PITUITARY-ADRENAL AXIS, IN-VIVO, CHINESE POPULATION, ASSOCIATION, SENSITIVITY, STRESS, RISK, BCLI
  • Marmara Üniversitesi Adresli: Evet

Özet

Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.