2-mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats

Sener G. , Kabasakal L. , Sehirli O., Ercan F. , Gedik N.

HEPATOLOGY RESEARCH, vol.35, no.2, pp.140-146, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.hepres.2006.02.009
  • Title of Journal : HEPATOLOGY RESEARCH
  • Page Numbers: pp.140-146


The aim of this study was to assess the antioxidant and antifibrotic effects of chronic administration of 2-mercaptoethane sulfonate (MESNA) on oxidative liver damage and fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL).