Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model

Xu Y., Guo N., Dou D., Ran X., Liu C.

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, vol.35, no.4, pp.224-232, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.12932/ap0845
  • Journal Name: ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.224-232
  • Keywords: Compound 48/80, Histamine, Anaphylactoid reaction, Metabolomics, Ovalbumin, HYPERSENSITIVITY REACTIONS, OXIDATIVE STRESS, ASTHMA, MICE, LEUKOTRIENES, INJECTION, HISTAMINE, RELEASE, DRUGS, MEDIA
  • Marmara University Affiliated: No

Abstract

Background: Anaphylactoid reactions, accounting for more than 77% of all immune-mediated immediate hypersensitivity reactions, have become a serious threat to public health, but their effect mechanism is not clear and diagnostic tests are limited. Comprehensive metabolite analysis may reveal the anaphylactoid effect mechanism systematically and provide reference for future diagnostic purposes.