Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model


Xu Y., Guo N., Dou D., Ran X., Liu C.

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, cilt.35, sa.4, ss.224-232, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.12932/ap0845
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.224-232
  • Anahtar Kelimeler: Compound 48/80, Histamine, Anaphylactoid reaction, Metabolomics, Ovalbumin, HYPERSENSITIVITY REACTIONS, OXIDATIVE STRESS, ASTHMA, MICE, LEUKOTRIENES, INJECTION, HISTAMINE, RELEASE, DRUGS, MEDIA
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background: Anaphylactoid reactions, accounting for more than 77% of all immune-mediated immediate hypersensitivity reactions, have become a serious threat to public health, but their effect mechanism is not clear and diagnostic tests are limited. Comprehensive metabolite analysis may reveal the anaphylactoid effect mechanism systematically and provide reference for future diagnostic purposes.