Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency

Sünter G., Enver E. O., Akbarzade A., Turan S., Vatansever P., Günal D., ...Daha Fazla

BMC NEUROLOGY, cilt.18, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1186/s12883-018-1049-9
  • Dergi Adı: BMC NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Sphingosine-1-phosphate lyase, Fingolimod, Adrenal, Multiple sclerosis, MULTIPLE-SCLEROSIS, NEPHROTIC SYNDROME, FINGOLIMOD, MUTATIONS, CELLS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by fingolimod which is an oral drug for relapsing multiple sclerosis (MS). Effects of this treatment on adrenal function has not yet been evaluated. We aimed to test adrenal function of MS patients receiving long-term fingolimod treatment.