Skin hyperreactivity of Behçet's patients (pathergy reaction) is also positive in interferon alpha-treated chronic myeloid leukaemia patients, indicating similarly altered neutrophil functions in both disorders.

Budak-Alpdoǧan T., Demirçay Z., Alpdoǧan Ö., DİRESKENELİ R. H., Ergun T., Öztürk A., ...More

British journal of rheumatology, vol.37, no.11, pp.1148-51, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 11
  • Publication Date: 1998
  • Doi Number: 10.1093/rheumatology/37.11.1148
  • Journal Name: British journal of rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1148-51
  • Keywords: Behcet's disease, chronic myeloid leukaemia, neutrophil function, pathergy reaction, CHRONIC MYELOGENOUS LEUKEMIA, DISEASE, SPECIFICITY, SENSITIVITY
  • Marmara University Affiliated: Yes

Abstract

Typical manifestations of Behcet's disease (BD) and a positive pathergy reaction were observed in a few patients with chronic myeloid leukaemia (CML) on interferon alpha (IFN-α) therapy and the significance of this observation was assessed in a prospective study. The skin pathergy test was applied to 15 patients with CML prior to IFN-α therapy, 29 patients with CML following IFN-α therapy and 30 patients with BD. Twenty five patients with inflammatory arthropathies (IA), 20 patients with recurrent oral ulcers (ROU), 23 patients treated with IFN-α for various disorders and 20 normal individuals were also studied as control groups. The pathergy reaction was positive in nearly a quarter of IFN-α-treated CML cases (24%) as well as one-half of the patients with BD (50%). All CML patients prior to IFN-α treatment and all patients using IFN-α for other diseases were negative for the pathergy reaction. These results may indicate a similarly altered neutrophil function in both BD and IFN-α-treated CML patients.