Age-related differences in oxidative protein-damage in young and senescent fibroblasts

Jung T., Hoehn A., Catalgol B., Grune T.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, cilt.483, sa.1, ss.127-135, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 483 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.abb.2008.12.007
  • Dergi Adı: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.127-135
  • Anahtar Kelimeler: Protein oxidation, Protein carbonyls, Senescence, Stress-induced-premature-senescence (SIPS), Lipofuscin, UBIQUITIN-PROTEASOME SYSTEM, HUMAN-DIPLOID FIBROBLASTS, OXIDIZED PROTEINS, PREMATURE SENESCENCE, LIPOFUSCIN ACCUMULATION, CELLULAR SENESCENCE, INTRACELLULAR-DISTRIBUTION, LIPID-PEROXIDATION, LYSOSOMAL STORAGE, HUMAN-DISEASES
  • Marmara Üniversitesi Adresli: Hayır

Özet

Aging is accompanied by an accumulation of oxidized proteins and cross-linked modified protein material. The intracellular formation and accumulation of highly oxidized and cross-linked proteins, the so-called lipofuscin, is a typical sign of senescence. However, little is known whether the lipofuscin accumulation during aging is related to environmental conditions, as oxidative stress, and whether the accumulation of oxidized proteins and lipofuscin is preferentially taking place in the cytosol or the nucleus and finally, what is the role of lysosomes in this process.