Age-related differences in oxidative protein-damage in young and senescent fibroblasts


Jung T., Hoehn A., Catalgol B. , Grune T.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, cilt.483, sa.1, ss.127-135, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 483 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.abb.2008.12.007
  • Dergi Adı: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
  • Sayfa Sayıları: ss.127-135

Özet

Aging is accompanied by an accumulation of oxidized proteins and cross-linked modified protein material. The intracellular formation and accumulation of highly oxidized and cross-linked proteins, the so-called lipofuscin, is a typical sign of senescence. However, little is known whether the lipofuscin accumulation during aging is related to environmental conditions, as oxidative stress, and whether the accumulation of oxidized proteins and lipofuscin is preferentially taking place in the cytosol or the nucleus and finally, what is the role of lysosomes in this process.