Bitter melon (Momordica charantia) fruit extract ameliorates methotrexate-induced reproductive toxicity in male rats

Kanpalta F., Özbeyli D., Şen A., Çevik Ö., Sener G., Ercan F.

MARMARA MEDICAL JOURNAL, cilt.34, sa.3, ss.222-228, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5472/marumj.988941
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.222-228
  • Anahtar Kelimeler: Methotrexate, Bitter melon, Testis, Epididymis, Oxidative stress, GROWTH, INJURY, MAP30
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage.