Bitter melon (Momordica charantia) fruit extract ameliorates methotrexate-induced reproductive toxicity in male rats

Kanpalta F., Özbeyli D., Şen A., Çevik Ö., Sener G., Ercan F.

MARMARA MEDICAL JOURNAL, vol.34, no.3, pp.222-228, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5472/marumj.988941
  • Journal Name: MARMARA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.222-228
  • Keywords: Methotrexate, Bitter melon, Testis, Epididymis, Oxidative stress, GROWTH, INJURY, MAP30
  • Marmara University Affiliated: Yes

Abstract

Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage.