The effects of aminoguanidine on serum paraoxanase activity in streptozotocin-induced diabetic rats

Parmaksiz I., Atak P. G., Yavuz D., ŞİRİKÇİ Ö.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.36, sa.4, ss.329-333, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2011
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.329-333
  • Marmara Üniversitesi Adresli: Evet

Özet

Aim: Diabetes is a systemic disease with increased oxidative damage, lipid oxidation and decreased prevention of LDL oxidation. Some of the preventive effects of HDL is thought to be mediated by paraoxanase. Paraoxonase activity is reduced in diabetes. Aminoguanidine, inhibits the formation of advanced glycation endproducts by reacting with intermediate products of glycation. We aimed to investigate the effects of the inhibition of advanced glycation by aminoguanidine on paraoxonase activity in a diabetes model.