Akademik Veri Yönetim Sistemi
5. International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 23 - 25 Kasım 2022, cilt.1, ss.1420-1427
Abstract
Fungi are living organisms that do not contain chlorophyll and
reproduce as parasites or saprophytes via spores. Cordyceps militaris, a genus
of Cordyceps, has been used therapeutically for centuries in traditional
Chinese medicine. Cordyceps militaris contains cordycepin, adenosine,
cordycepic acid, superoxide dismutase enzyme and cordyceps polysaccharides with
biological and pharmacological activities. Cordycepin is a biologically active
broad-spectrum nucleoside analogue and was originally derived from Cordyceps
militaris. In our study, a review was created by examining the analytical
studies on the antioxidant activity of Cordyceps militaris and the
determination of the bioactive compounds it contains. In the review study, the
antioxidant properties and phenolic components of Cordyceps militaris were
obtained by searching the literature with Springer, PubMed, Web of Science,
Science Direct and Scopus databases. From the information obtained by various
spectrophotometric methods, DPPH(1,1-Diphenyl-2-picrylhydrazil), ABTS•+(2,2`azinobis
(3-ethylbenzothiazoline-6-sulfonic) acid), FRAP(iron (III) ion reducing
antioxidant power method), Oxygen Radical Absorbance Capacity (ORAC) Method,
Hydroxy radical capture activity and Folin-Ciocalteu reagent (FCR), TEAC
(Trolox equivalent antioxidant capacity) methods were investigated. Looking at
the data, it was determined that Cordyceps militaris contains polysaccharides
with important bioactive properties, which are known to be antiviral,
antioxidant, anti-inflammatory, antitumor, neuroprotective, antihypertensive
and immunomodulatory. These polysaccharides have been proven to have
liver-protective, kidney-protective, neuroprotective, immunomodulatory,
antidiabetes, anticancer, and antioxidant effects. Many health products in
China contain Cordyceps militaris. It is known that drugs produced from the
Cordyceps militaris plant are used for kidney, lung health, delaying aging and
sleep, regulators. Considering these data, it can be recommended to be used in
supportive treatment in medicine under the control of a doctor.
Keywords: Cordyceps militaris, Cordycepin, Antioxidant
Activity Methods, Bioactive compounds.