Metastatic Mucinous Adenocarcinoma of Unknown Origin Showing 68Ga-DOTATATE Uptake

Filizoglu N., ÖZGÜVEN S., DEDE F., TUROĞLU H. T., ERDİL T. Y.

Clinical Nuclear Medicine, vol.50, no.1, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.1097/rlu.0000000000005548
  • Journal Name: Clinical Nuclear Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Keywords: 68Ga-DOTATATE PET/CT, metastasis, mucinous adenocarcinoma, nonneuroendocrine tumors
  • Marmara University Affiliated: Yes

Abstract

Although the use of 18F-FDG PET/CT is well established in the evaluation of adenocarcinoma, the performance of 18F-FDG PET/CT in mucinous adenocarcinoma is not consistent. 68Ga-DOTATATE uptake can be observed in some non-neuroendocrine tumors as a result of tumor blood flow and somatostatin receptor expression at different levels. For this reason, 68Ga-DOTATATE PET/CT may have a prospective role in the evaluation of mucinous adenocarcinoma. However, there is no published case of mucinous adenocarcinoma with 68Ga-DOTATATE uptake. We present a unique case of metastatic mucinous adenocarcinoma of unknown origin on 68Ga-DOTATATE PET/CT.