Mazı C., Karaderi S., Arıöz F.
Journal of Chemistry and Materials Research, cilt.10, ss.61-67, 2018 (Hakemli Dergi)
Özet
Abstract
To develop a simple, accurate, precision and
economical UV-Vis spectrophotometric and mole ratio method for the analysis in
pharmaceutical formulations by making its complexes with calcium(II) and
magnesium(II). In this study, the separately spectrums of Valsartan and the
complexes occured between Ca2+ and Mg2+ metal ions were
taken in ultra-violet area. In addition, stoichiometric ratios of the complexes
occured between Valsartan with Ca2+ and Mg2+ metal ions
were determined using mole ratio method. The wavelength of maximum absorption
of the spectrum Valsartan and metal complexes with Ca(II) and Mg(II) were
determined. The experimental data indicate the formation of metal:ligand = 1:1
complexes for Ca(II)-Valsartan and Mg(II)-Valsartan. Valsartan’s recovery rate,
it was found in the range of 92.0– 97.5%. Beer’s obeyed in the concentration
range of 2.18 -10.89 µg/mL for VAL. The LOD and LOQ were found to be 2.21 µg/mL
and 10.9 µg/mL for Valsartan respectively. It is considered that the complexes
between Valsartan with Ca2+ and Mg2+ metal ions would
affect treatments positively or negatively.