The effects of melatonin on the striatum

Gergin S., KİRAZLI Ö., Boraci H., Yildiz S. D., ŞEHİRLİ Ü. S.

MARMARA MEDICAL JOURNAL, cilt.34, sa.3, ss.234-240, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5472/marumj.1012077
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.234-240
  • Anahtar Kelimeler: Dendritic spine, Melatonin, Golgi, Neurolucida, DENDRITIC SPINE PATHOLOGY, L-DOPA, NEURONS, MORPHOLOGY, DENSITY, PLASTICITY, CORTEX
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Some of the neurological diseases cause morphologic changes in the striatal neurons. Medial forebrain bundle (MFB) lesion is a commonly used method to produce a Parkinsonian model rat. Melatonin is a hormone which exerts a neuroprotective effect on the neurons. The aim of this study is to investigate the effect of melatonin on the dendritic morphology of striatal medium spiny neurons (MSNs) in rats with MFB lesion.