Akademik Veri Yönetim Sistemi
JOURNAL OF COORDINATION CHEMISTRY, cilt.78, sa.13, ss.1504-1514, 2025 (SCI-Expanded, Scopus)
Pseudomonas aeruginosa is a major cause of nosocomial infections in hospitals. P. aeruginosa regulates its virulence gene expressions via quorum sensing (QS) systems. Inhibition of QS systems can decrease virulence factors and leave the bacteria vulnerable. Therefore, it is necessary to identify novel QS inhibitor (QSI) compounds. This study aims to investigate synthesized phthalocyanine compounds for their antivirulence potential against P. aeruginosa via in silico and in vitro methods. Molecular docking simulations were performed for synthesized phthalocyanine compounds, metal salt derivatives (Pc, ZnPc, and CoPc), and QS-related proteins. Moreover, they were applied to biomonitor strains to observe QS inhibitions, which were validated by virulence assays. Significant inhibition ratios were observed for all tested compounds against P. aeruginosa QS systems. Results indicate that phthalocyanine compounds used in this study have the potential to be utilized in antivirulence strategies.