Outcome measures for Takayasu's arteritis


Aydin S. Z. , Merkel P. A. , Direskeneli H.

CURRENT OPINION IN RHEUMATOLOGY, vol.27, no.1, pp.32-37, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1097/bor.0000000000000129
  • Title of Journal : CURRENT OPINION IN RHEUMATOLOGY
  • Page Numbers: pp.32-37
  • Keywords: disease assessment, outcome measures, Takayasu's arteritis, QUALITY-OF-LIFE, LARGE-VESSEL VASCULITIS, DISEASE-ACTIVITY, CLINICAL-TRIALS, DIAGNOSIS, MANAGEMENT, EFFICACY, HEALTH, INTERVENTION, PROGRESSION

Abstract

Purpose of reviewTakayasu's arteritis (TAK) is a large-vessel vasculitis with a chronic, indolent course affecting the aorta and its main branches. This review will describe the recent studies to develop validated outcome measures to assess TAK.Recent findingsTAK is traditionally assessed with a physician's global assessment including symptoms and signs of inflammation and vascular insufficiency, acute-phase reactants (APRs), and imaging including conventional digital subtraction angiography, computerized tomographic, and magnetic resonance angiography, and recently 18-FDG-PET. Recent attempts to develop a validated tool for disease assessment include the Indian Takayasu Clinical Activity Score (ITAS2010), which incorporates clinical signs and symptoms with APRs in a simplified and weighted adoption of the Birmingham Vasculitis Activity Score. Among biomarkers to assess clinical activity, pentraxin-3 is perhaps the most promising, but its validity and superiority against APRs in clinical practice need to be demonstrated. Patient-reported outcomes (PROs) are increasingly recognized as of substantial importance to measure in clinical trials; in addition to so-called generic' tools such as the SF-36 or measures of fatigue, disease-specific instruments would likely help capture aspects of TAK not measured by generic quality-of-life assessments or physician-based tools.SummaryAlthough outcome measures for TAK are not sufficiently validated, progress in the assessment of TAK is reflected in recent studies with new tools such as ITAS2010, new biomarkers, and a variety of PROs.