In vitro mircosomal metabolism of N-benzyl and N-benzoylnornicotine derivates by rat

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Atıf İçin Kopyala

Yilmaz F., Kartal F., Ulgen M., Gorrod J.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, sa.4, ss.249-256, 2004 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 29 Sayı: 4
• Basım Tarihi: 2004
• Doi Numarası: 10.1007/bf03190607
• Dergi Adı: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.249-256
• Marmara Üniversitesi Adresli: Evet

Özet

The in vitro hepatic microsomal metabolism of N-1'-benzylnornicotine, N-1'-(p-chlorobenzyl)nornicotine, N-1'-benzoylnornicotine and N-1'-(p-chlorobenzoyl) nornicotine was studied using hepatic washed rat microsomal preparations fortified with NADPH. Substrates and their potential metabolites were synthesized, characterised by spectral methods, and separated using a reverse phase HPLC system consisted of a C-18 column and a mobile phase composition of acetonitrile: phosphate buffer.