In vitro mircosomal metabolism of N-benzyl and N-benzoylnornicotine derivates by rat


Yilmaz F., Kartal F. , Ulgen M., Gorrod J.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, ss.249-256, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/bf03190607
  • Dergi Adı: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Sayfa Sayıları: ss.249-256

Özet

The in vitro hepatic microsomal metabolism of N-1'-benzylnornicotine, N-1'-(p-chlorobenzyl)nornicotine, N-1'-benzoylnornicotine and N-1'-(p-chlorobenzoyl) nornicotine was studied using hepatic washed rat microsomal preparations fortified with NADPH. Substrates and their potential metabolites were synthesized, characterised by spectral methods, and separated using a reverse phase HPLC system consisted of a C-18 column and a mobile phase composition of acetonitrile: phosphate buffer.