In vitro mircosomal metabolism of N-benzyl and N-benzoylnornicotine derivates by rat
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, sa.4, ss.249-256, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1007/bf03190607
- Dergi Adı: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.249-256
- Marmara Üniversitesi Adresli: Evet
Özet
The in vitro hepatic microsomal metabolism of N-1'-benzylnornicotine, N-1'-(p-chlorobenzyl)nornicotine, N-1'-benzoylnornicotine and N-1'-(p-chlorobenzoyl) nornicotine was studied using hepatic washed rat microsomal preparations fortified with NADPH. Substrates and their potential metabolites were synthesized, characterised by spectral methods, and separated using a reverse phase HPLC system consisted of a C-18 column and a mobile phase composition of acetonitrile: phosphate buffer.