Tailoring Corynebacterium glutamicum for Sustainable Biomanufacturing: From Traditional to Cutting-Edge Technologies
Molecular Biotechnology, cilt.68, sa.3, ss.1106-1126, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 68 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s12033-025-01447-z
- Dergi Adı: Molecular Biotechnology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Compendex, Food Science & Technology Abstracts, Index Islamicus, INSPEC, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1106-1126
- Anahtar Kelimeler: Corynebacterium glutamicum, Genome engineering, High-throughput analysis, Machine learning, Transcription modulation
- Marmara Üniversitesi Adresli: Evet
Özet
As the workhorse of industrial amino acid production, Corynebacterium glutamicum is the focus of this review, which provides a comprehensive overview of available techniques employed to engineer strains with desired traits. The review highlights both traditional and cutting-edge approaches with a brief introduction to the bacterium’s physiology, serving as a foundation for understanding its metabolic capabilities and potential applications. Genome modulation techniques by contrasting traditional methods with CRISPR-based approaches, as well as transcription modulation strategies that enhance gene expression and metabolic flux, and high-throughput techniques that streamline strain development processes are summarized. Furthermore, the roles of artificial intelligence and machine learning in genetic engineering are explored, emphasizing their growing impact on strain development.