Estrogen protects the liver and intestines against sepsis-induced injury in rats


Sener G. , Arbak S., Kurtaran P., Gedik N., Yegen B.

JOURNAL OF SURGICAL RESEARCH, vol.128, no.1, pp.70-78, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2005.02.019
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.70-78
  • Keywords: estrogens, lipid peroxidation, glutathione, TNF-alpha, sepsis, LIPID-PEROXIDATION, MELATONIN TREATMENT, FREE-RADICALS, SEX-HORMONES, BURN INJURY, ANTIOXIDANT, GLUTATHIONE, STEROIDS, FAILURE, SHOCK

Abstract

Background and aim. Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, leading to multiple organ dysfunctions. The aim of this study was to examine the putative protective role of estradiol against sepsis-induced oxidative organ damage.