In silico investigation of wound healing potential of some compounds in tubers of Asphodelus species with GSK3-β protein

AKSOY H., ŞEKERLER T., MERT N. M.

Journal of Research in Pharmacy, cilt.25, sa.5, ss.747-754, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.29228/jrp.65
  • Dergi Adı: Journal of Research in Pharmacy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.747-754
  • Anahtar Kelimeler: Asphodelus species, beta-sitosterol, emodin, GSK3-beta protein, stigmasterol, wound healing activity, GLYCOGEN-SYNTHASE KINASE-3-BETA, DOCKING
  • Marmara Üniversitesi Adresli: Evet

Özet

Wound healing is a process that involves biochemical processes such as inflammation and cell proliferation and is controlled by many proteins. It is known that one of the most effective factors in this process is the inhibition of GSK3-beta protein. In current study, in silico wound healing activity of the some compounds found in the tubers of Asphodelus species used as a wound healing in traditional medicine were investigated. For this purpose, the interactions between the compounds and GSK3-beta protein were studied in silico. As a result of the study, it has been determined that and stigmasterol, beta-sitosterol and emodin molecules are effective.