Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children

Bereket A. , Lang C., Blethen S., Ng L., Wilson T.

CLINICAL ENDOCRINOLOGY, cilt.45, sa.3, ss.321-326, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier


OBJECTIVE We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically available IGF-I in the serum have not been examined directly in diabetic children, In the present study, the effect of diabetes and subsequent insulin replacement on the circulating free IGF-l concentrations are assessed,