Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children

Bereket A., Lang C., Blethen S., Ng L., Wilson T.

CLINICAL ENDOCRINOLOGY, vol.45, no.3, pp.321-326, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 1996
  • Doi Number: 10.1046/j.1365-2265.1996.7760786.x
  • Journal Name: CLINICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.321-326
  • Marmara University Affiliated: No

Abstract

OBJECTIVE We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically available IGF-I in the serum have not been examined directly in diabetic children, In the present study, the effect of diabetes and subsequent insulin replacement on the circulating free IGF-l concentrations are assessed,