Synthesis and anticonvulsant activity of some 2-pyrazolines derived from chalcones

Beyhan N., Kocyigit-Kaymakcioglu B., Gumru S., ARICIOĞLU F.

ARABIAN JOURNAL OF CHEMISTRY, cilt.10, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.arabjc.2013.07.037
  • Dergi Adı: ARABIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Chalcones, 2-Pyrazolines, Carbothioamide, Carboxyamide, Anticonvulsant activity, PHARMACOLOGICAL-PROPERTIES, DERIVATIVES, DRUGS
  • Marmara Üniversitesi Adresli: Evet

Özet

Synthesis of chalcones (1,3-diarylprop-2-en-1-ones) and 2-pyrazoline derivatives has been an active field of research due to their established pharmacological effects. In this study, a series of chalcones were prepared with methyl aryl ketones and substituted aldehydes in the presence of sodium hydroxide and methanol through Claisen-Schmidt condensation. 3,5-Disubstituted4,5-dihydro-1H-pyrazole-1-carbothioamides were synthesized by refluxing selected chalcones and thiosemicarbazide in alkaline medium. Similarly N-3,5-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides were synthesized by refluxing selected chalcones with N-(4-chlorophenyl) semicarbazide in alkaline medium. Structures of the synthesized compounds were confirmed by elemental analysis and spectral (UV, IR, H-1 NMR, C-13 NMR, and mass) data, which were in line with the proposed structures.