This study was carried out among the newborns to establish the efficacy and reliability of a cream including local analgesic substances (lidocaine and prilocaine). The study group consisted of 50 cases, 28 of them were preterm (56 %), of them were term babies (44 %). EMLA cream (5 %) or placebo were applied randomized on the cases. That cream was produced by an English laboratory, numerated from 1 to 50, and packed in aluminium coated tubes. The signs of each case were registered on a questinary form. The local reactions and the reactions to the pain stimulus after an hour of the application were evaluated. The responses to the stimulus (pricking the heel with a lancet) were grouped in 'crying', 'the change in colour', 'the alteration in respiration', 'pulling away the foot'. As the result the pain reaction in the EMLA group were less than in the placebo group. The difference was significant and it was independent of the state reaction of the newborn at that moment. The absence of local reactions also support the reliability of the application of that drug.