Stem cell therapies in post-prostatectomy erectile dysfunction: a critical review


Mangir N., Turkeri L.

CANADIAN JOURNAL OF UROLOGY, cilt.24, sa.1, ss.8609-8619, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2017
  • Dergi Adı: CANADIAN JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8609-8619
  • Anahtar Kelimeler: radical prostatectomy, cavernous nerve injury, mesenchymal stem cells, erectile dysfunction, MESENCHYMAL STROMAL CELLS, RAT MODEL, RADICAL PROSTATECTOMY, VASCULAR FRACTION, FUNCTION RECOVERY, IN-VITRO, PERIPROSTATIC IMPLANTATION, INTRACAVERNOSAL INJECTION, PENILE ERECTION, EXPRESSION
  • Marmara Üniversitesi Adresli: Evet

Özet

Introduction: Erectile dysfunction (ED) is still a common complication of radical prostatectomy. Current treatments of ED are mainly symptomatic. Mesenchymal stem cells (MSCs) have been widely investigated as a potential curative treatment. Although MSC therapy consistently improved erectile functions in the pre-clinical studies the initial expectations seem to be unmet. The aim of this study is to critically review the existing studies on use of stem cells in post-prostatectomy ED and understand factors that preclude clinical translation of the available evidence.