Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2023 – Summer Edition, Bucuresti, Romanya, 26 - 30 Haziran 2023, ss.81-82
Skin infections are medical conditions caused by parasites, bacteria, viruses and fungi when these
microorganisms enters skin by having damaged skin or simply with insect bite, mostly skin infections can
be recognized with edema, erythema, lesions and other inflammation signs [1]
Globally according to systemic study covered skin diseases analysis between 1990 and 2019 the
number of bacterial skin diseases patients is increasing with rate of change of age standarized (7.38%) [2],
this study raised the awarness about finding ways to prevent the formulation of skin infections and treating
it in effective way.
Traditional methods in treating skin infections includes the herbal treatments that were used form
ancient centuries (e.g. Achyranthes aspera , Aloe vera,...), these herbs have proved its effectivness with
more than 80% cured people in India which depends on traditional treatments for skin diseases [3].
Conventional treatment of skin infections includes the usage of antibiotics in its different forms, and
different mechanism of action according to the cause of the infection (gram positive or gram negative
bacteria). On the other hand, the dosage differ according to the form of antibiotics, and the antibiotic type[4]
Modern medicine of treating skin infections includes the usage of new drug delivery systems which
applies the usage of biomaterials (polymers, ceramics, metals, composites) at different size scales (macro,
micro, nano) that help in reducing the side effects of drugs, extend the half-life, and having optimal
pharmacokinetics processes for the targeted drug [5].
In the last two decades, the interset in developing new methods to deliver drugs has become more and
more; espically the deliver of antibiotics because of the increase in resistance on global scales. These
methods includes using different techniques such as electrospinning technique which produces fibers mainly
composed of polymers loaded with drugs, this technique is classified as promising method for personlized
medicine and the improvement of drug release profiles. [6]
In this work, we tried to focus on taking advantages of electrospinning technique to deliver minimum
amount of antibiotics (Gentamicin, Caffeic Acid) to skin for the treatment of skin infections away from
antibiotic resistance. Fibers were fabricated by loading antibiotics with Poly Lactic Acid polymeric solution
and produce fibers that can be used directly on skin with lower side effects and lower dosage when compared
to conventional methods of delivering drugs. Morphological, mechanical, thermal, chemical analysis were
ivestigated for the fabricated fibers; in addition to swelling antimicrobial, drug release profiles.