Brucellosis presenting with pancytopenia due to hemophagocytic syndrome

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Erdem E. , Yildirmak Y., Gunaydin N.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, ss.68-71, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.09
  • Sayfa Sayıları: ss.68-71


Reactive hemophagocytic syndrome is clinically characterized by fever, hepatosplenomegaly, pancytopenia, and coagulopathy, and is histologically characterized by excessive proliferation and activation of histiocytes or macrophages. It can occur with systemic infections, immunodeficiency, or underlying malignancy. Brucellosis is one of the rare causes of hemophagocytosis. Herein we report an 11-year-old male with pancytopenia due to hemophagocytosis during the course of brucellosis that responded favorably to therapy. Although rare, hemophagocytosis should be considered as a possible cause of pancytopenia in patients with brucellosis, especially in regions where brucellosis is frequently encountered. (Turk J Hematol 2011; 28: 68-71)