The Effect of Vitamin D Treatment on Advanced Glycation End-Products in Patients with Prediabetes and Type 2 Diabetes Mellitus

Cetin B. T., Bayram F. B., YAVUZ D.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.27, sa.2, ss.54-58, 2023 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.5152/erp.2023.22139189
  • Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.54-58
  • Anahtar Kelimeler: Vitamin D, type 2 diabetes, serum carboxymethyl lysine, skin autofluorescence, AGE, SKIN AUTOFLUORESCENCE, 25-HYDROXYVITAMIN D, SERUM-LEVELS, D DEFICIENCY, GLYCOXIDATION, PREVENTION, ENDPRODUCTS, PROGRESSION, MORTALITY, RISK
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to investigate the role of vitamin D replacement therapy on advanced glycation end-products in prediabetes and type 2 diabetes mellitus patients with vitamin D deficiency. Methods: One hundred twenty subjects with serum 25-hydroxyl vitamin D levels less than 20 ng/mL were included in the study. Forty type 2 diabetes mellitus patients (type 2 diabetes mellitus group), 40 prediabetes patients (prediabetes group), and 40 non-diabetes controls (non-diabetes group) were given oral vitamin D3 50 000 units/week for 8 weeks as loading and followed by 1500 U/day as a maintenance dose. We measured serum 25-hydroxyl vitamin D, glycated hemoglobin, carboxymethyl lysine levels, and skin autofluorescence before and on the fourth month of the therapy. Results: Basal serum carboxymethyl lysine and skin autofluorescence measurement in type 2 diabe-tes mellitus and prediabetes groups were significantly higher than the non-diabetes group. While no difference was found between glycated hemoglobin and skin autofluorescence, serum carboxy-methyl lysine levels were significantly elevated for each group following vitamin D replacement. Conclusions: Vitamin D loading did not affect skin advanced glycation end-product levels and gly-cated hemoglobin but was associated with increased serum carboxymethyl lysine levels in all groups.