Akademik Veri Yönetim Sistemi
8th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 17 - 19 Aralık 2025, ss.1221-1228, (Tam Metin Bildiri)
Bone tissue is vital for providing mechanical support, mineral storage, and maintaining biological functions in the body. The treatment of bone defects resulting from trauma, tumors, or degenerative diseases continues to pose a significant clinical challenge. Therefore, hydroxyapatite (HA, Ca₁₀(PO₄)₆(OH)₂), which is highly similar to bone tissue in terms of chemical and structural properties, has emerged as an important ceramic phase in tissue engineering and biomaterials research. Thanks to its high biocompatibility, bioactivity, and osteoconductive properties, HA is one of the most suitable materials to support bone regeneration. Hydroxyapatite can be obtained synthetically, and studies have demonstrated that HA derived from natural sources exhibits biological performance similar to or even superior to synthetic elastics. However, the brittle nature and low mechanical strength of pure HA limit its use on its own. Therefore, in recent years, composite systems composed of natural (gelatin, chitosan, alginate, etc.) and synthetic (PLGA, PCL, PLLA, etc.) polymers have been developed. These structures have been shown to yield successful results in terms of cell adhesion, tissue integration, and controlled drug release. Furthermore, ion-doped or surface-modified HA structures are reported to enhance antibacterial, osteogenic, and piezoelectric properties. Current studies reveal the versatile potential of HA-based nanocomposites in bone tissue engineering and drug delivery systems. However, long-term biosafety, biodegradability, and performance evaluations are needed to translate the obtained preclinical findings into clinical applications.