Age-related macular degeneration and Alzheimer disease

ÇERMAN E., ERASLAN M., ÇEKİÇ O.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.5, ss.1004-1009, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1406-146
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1004-1009
  • Anahtar Kelimeler: Age-related macular degeneration, Alzheimer disease, amyloid-beta, drusen, senile plaques, SOLUBLE AMYLOID OLIGOMERS, COMPLEMENT ACTIVATION, OXIDATIVE STRESS, APOLIPOPROTEIN-E, POTENTIAL ROLE, BETA PEPTIDES, RISK-FACTORS, BLOOD-FLOW, DRUSEN, PATHOGENESIS
  • Marmara Üniversitesi Adresli: Evet

Özet

This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-beta accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.