Proteasome and Neurodegenerative Diseases


Catalgol B. , Grune T.

THE PROTEASOMAL SYSTEM IN AGING AND DISEASE, cilt.109, ss.397-414, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 109
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/b978-0-12-397863-9.00011-0
  • Dergi Adı: THE PROTEASOMAL SYSTEM IN AGING AND DISEASE
  • Sayfa Sayıları: ss.397-414

Özet

Proteasomal degradation of damaged proteins is involved in the pathogenesis of many neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, stroke, and amyotrophic lateral sclerosis. A malfunction of the proteasomal activity may be the result or the consequence of protein aggregation, which is a key process for most neurodegenerative diseases. Because of the widespread aspects of the proteasomal involvement in the progression of these diseases, many studies are focused on this research.