Proteasome and Neurodegenerative Diseases
THE PROTEASOMAL SYSTEM IN AGING AND DISEASE, cilt.109, ss.397-414, 2012 (SCI-Expanded)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 109
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/b978-0-12-397863-9.00011-0
- Dergi Adı: THE PROTEASOMAL SYSTEM IN AGING AND DISEASE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.397-414
- Marmara Üniversitesi Adresli: Evet
Özet
Proteasomal degradation of damaged proteins is involved in the pathogenesis of many neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, stroke, and amyotrophic lateral sclerosis. A malfunction of the proteasomal activity may be the result or the consequence of protein aggregation, which is a key process for most neurodegenerative diseases. Because of the widespread aspects of the proteasomal involvement in the progression of these diseases, many studies are focused on this research.