Harmane induces anxiolysis and antidepressant-like effects in rats

Aricioglu F., Altunbas H.

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES, cilt.1009, ss.196-200, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1009
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1196/annals.1304.024
  • Dergi Adı: AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.196-200
  • Anahtar Kelimeler: harmane, forced swim test, elevated plus maze, imidazoline, benzodiazepine, monoamine oxidase, BETA-CARBOLINE BINDING, OXIDASE SUBTYPE-A, MONOAMINE-OXIDASE, NORHARMAN, INHIBITOR, AFFINITY, URINE
  • Marmara Üniversitesi Adresli: Hayır

Özet

A forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.