Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2022 – Winter Edition, Bucuresti, Romanya, 24 - 26 Kasım 2022, ss.45-46
A chronic medical disease known as epilepsy typically causes spontaneous, unprovoked repeated
seizures that have an impact on a variety of mental and physical activities. The majority of epilepsy patients
can manage their seizures with medical treatment. More than one-third of patients who do not receive
adequate benefit from oral antiepileptic drug therapy continue to have seizures. It is considered as a proper
option to design local drug release to the focal area of the brain where the seizure occurs in order to reduce
side effects of antiepileptic drugs and to increase therapeutic efficacy by providing higher and more effective
doses to the seizure focus. This study concentrates on polymer-based implants, which are polymeric devices
loaded with AED and designed for implantation at the seizure focus to provide gradual, prolonged release
of AED directly into the area of the brain responsible for seizures. Ethosuximide, an antiepileptic drug used
in the treatment of absence seizures, was chosen as the active ingredient in this study. With 3D printing,
implantable scaffolds consisting of Alginate and polyethylene oxide polymers and containing the active
substance ethosuximide were produced. The properties of drug-containing polymeric scaffolds were
investigated by SEM analysis, and their chemical and thermal properties were analyzed using DSC and FTIR, respectively. The drug release of the scaffolds was tested in vitro. In this study, human neuroblastoma
cell line, SH-SY5Y (CRL-2266™, ATCC) was used for toxicity analysis.