The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy

Carcak N., Aker R., Oezdemir O., Demiralp T., ONAT F.

NEUROBIOLOGY OF DISEASE, cilt.32, sa.3, ss.355-363, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.nbd.2008.07.018
  • Dergi Adı: NEUROBIOLOGY OF DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.355-363
  • Anahtar Kelimeler: Temporal lobe epilepsy model, Absence epilepsy model, GAERS, Amygdaloid stimulation, Limbic seizures, Kindling resistance, ELECTRICAL-STIMULATION, SEIZURES, MECHANISMS, MODEL, EXPRESSION, NEURONS
  • Marmara Üniversitesi Adresli: Evet

Özet

Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are resistant to amygdaloid kindling. Since in GAERS the characteristics of spike-and-wave discharges (SWDs) change with age, we have studied the relation between SWD maturation and the development of kindling resistance. Non-epileptic Wistar rats and GAERS were stimulated in basolateral amygdala with 400 mu A at 20 min intervals until they reached stage 5 seizures or for a maximum of 36 stimulations. All of the Wistar rats, the postnatal (PN) day 20 GAERS and the (kindling-prone) subgroups of GAERS at PN30 and PN60 reached stage 5 seizures; at PN20, PN30 and PN60 kindling rates were significantly slower in GAERS compared to Wistar rats. At PN30 and PN60, 41% and 69% of GAERS, respectively, showed no stage 3, 4 or 5 seizures after 36 stimulations (kindling-resistant subgroups). The SWD maturation involves changes in spectral patterns and correlate with age-related increases in kindling resistance in GAERS. (C) 2008 Elsevier Inc. All rights reserved.