Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?


ÖZBEN SADIÇ B. , Altun I., Hancer V. S. , Bilge A. K. , Tanrikulu A. M. , Diz-Kucukkaya R., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.9, ss.215-220, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 9 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1470320308099126
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Sayfa Sayıları: ss.215-220

Özet

Introduction. Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable disorder characterised by fibrofatty replacement of right ventricular myocytes and increased risk of ventricular arrhythmias and sudden cardiac death. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D)) polymorphism affects myocardial ACE levels. DD genotype favours myocardial fibrosis and is associated with malignant ventricular tachycardia. The aim of this study was to explore ACE gene polymorphism in ARVD patients.