Tetra vs. octa-How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines

TOPKAYA TAŞKIRAN D., Aydin D., Ben Aziza H., ŞAHİN Z., İŞCİ Ü., Durand D., ...More

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.26, no.11, pp.701-707, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1142/s1088424622500584
  • Journal Name: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica
  • Page Numbers: pp.701-707
  • Keywords: Phthalocyanine, mercaptophenol, singlet oxygen generation, photodynamic therapy, in vitro, PHOTODYNAMIC THERAPY, PERIPHERAL SUBSTITUTION, ZINC PHTHALOCYANINE, PHOTOSENSITIZERS
  • Marmara University Affiliated: Yes

Abstract

Zn phthalocyanines tetra- and octa- substituted in peripheral positions by mercaptophenol moieties were prepared. Photophysical, photochemical, physicochemical and biological properties relevant from a photodynamic therapy point of view have been determined, showing that the tetra-substituted derivatives have better potential, confirmed by in vitro tests performed on MCF-7 cells that induced significant cell death without showing dark toxicity.