Tetra vs. octa-How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines

TOPKAYA TAŞKIRAN D., Aydin D., Ben Aziza H., ŞAHİN Z., İŞCİ Ü., Durand D., ...Daha Fazla

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.26, sa.11, ss.701-707, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1142/s1088424622500584
  • Dergi Adı: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica
  • Sayfa Sayıları: ss.701-707
  • Anahtar Kelimeler: Phthalocyanine, mercaptophenol, singlet oxygen generation, photodynamic therapy, in vitro, PHOTODYNAMIC THERAPY, PERIPHERAL SUBSTITUTION, ZINC PHTHALOCYANINE, PHOTOSENSITIZERS
  • Marmara Üniversitesi Adresli: Evet

Özet

Zn phthalocyanines tetra- and octa- substituted in peripheral positions by mercaptophenol moieties were prepared. Photophysical, photochemical, physicochemical and biological properties relevant from a photodynamic therapy point of view have been determined, showing that the tetra-substituted derivatives have better potential, confirmed by in vitro tests performed on MCF-7 cells that induced significant cell death without showing dark toxicity.