Polymorphisms of the tumour necrosis factor alpha gene at position-308 and TNFd microsatellite in primary IgA nephropathy

Tuglular S., Berthoux P., Berthoux F.

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.18, sa.4, ss.724-731, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1093/ndt/gfg010
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.724-731
  • Anahtar Kelimeler: gene polymorphism, genotype/phenotype correlation, IgA nephropathy, promoter region (-308), turnour necrosis factor alpha, TNFd microsatellites, RENAL-TRANSPLANTATION, PROMOTER REGION, GLOMERULONEPHRITIS, CYTOKINES, EXPRESSION, SEVERITY
  • Marmara Üniversitesi Adresli: Evet

Özet

Background. The development of glomerular inflammation in immunoglobulin A nephropathy (IgAN) has been associated with various cytokines, including tumour necrosis factor alpha (TNFalpha). A biallelic polymorphism in the promoter region of the TNFalpha gene (TNFA), at position -308, has been described (TNFA-1 and TNFA-2) and is associated with increased TNFalpha production for the TNFA-2 allele. Another microsatellite polymorphism has been described for TNFd, which is functional and associated with increased production of TNFalpha for the d3 allele.