Cytokine profiles in serum of patients with oral lichen planus

PEKİNER F. M., YANIKKAYA DEMİREL G., BORAHAN M. O., Ozbayrak S.

CYTOKINE, vol.60, no.3, pp.701-706, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.cyto.2012.08.007
  • Journal Name: CYTOKINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.701-706
  • Keywords: Oral lichen planus, Cytokine, T helper 1, T helper 2, NECROSIS-FACTOR-ALPHA, TNF-ALPHA, T-CELLS, IL-10, INTERLEUKIN-10, PATHOGENESIS, EXPRESSION, TH1
  • Marmara University Affiliated: Yes

Abstract

Objective: Oral lichen planus (OLP) is a chronic inflammatory disorder of oral mucosa, which represents T-cell-mediated autoimmune diseases. The inflammatory response in OLP is characterized by the accumulation and expansion of T-helper 1 (Th1) lymphocytes. Several lines of evidence have suggested that a complex cytokine network plays an important role in the exacerbation and perpetuation of OLP. The aim of this study was to evaluate Th1 and T-helper 2 (Th2) cytokine profile in serum of patients with OLP in comparison to healthy controls.