Cytokine profiles in serum of patients with oral lichen planus

PEKİNER F. M., YANIKKAYA DEMİREL G., BORAHAN M. O., Ozbayrak S.

CYTOKINE, cilt.60, sa.3, ss.701-706, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.cyto.2012.08.007
  • Dergi Adı: CYTOKINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.701-706
  • Anahtar Kelimeler: Oral lichen planus, Cytokine, T helper 1, T helper 2, NECROSIS-FACTOR-ALPHA, TNF-ALPHA, T-CELLS, IL-10, INTERLEUKIN-10, PATHOGENESIS, EXPRESSION, TH1
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Oral lichen planus (OLP) is a chronic inflammatory disorder of oral mucosa, which represents T-cell-mediated autoimmune diseases. The inflammatory response in OLP is characterized by the accumulation and expansion of T-helper 1 (Th1) lymphocytes. Several lines of evidence have suggested that a complex cytokine network plays an important role in the exacerbation and perpetuation of OLP. The aim of this study was to evaluate Th1 and T-helper 2 (Th2) cytokine profile in serum of patients with OLP in comparison to healthy controls.