Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering – NanoBioMat 2021, Bucuresti, Romanya, 25 - 27 Kasım 2021, ss.30, (Özet Bildiri)
Skin diseases are commonly treated with antihistamines, antibiotics, laser therapy, topical medications, local vitamins or steroids, and skin tissue engineering. Because conventional treatments for wound healing (skin allografts, amnion, xenografts etc.) have disadvantages such as antigenicity of the donor tissue, risk of infection or lack of basement membrane, skin tissue engineering became a popular new approach. Juglone (5-hydroxy-1,4-naphthoquinone) is an significant allelochemicals found in walnut trees and used as a bioactive material in this study and the effects of Juglone amount (1.25, 2.5, 5, 7.5, and 10 mg) on the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the 25% PCL 3D-printed scaffolds were investigated. The antimicrobial activity carried out against the Staphylococcus Aureus (S. aureus) and Escherichia coli (E. coli). Biocompatibility properties of the Juglone added scaffolds were examined using fibroblast cell line. The morphological properties of the scaffolds were examined with scanning electron microscopy. In addition, mechanical performance of the scaffolds also were analyzed with tensile testing to determine the mechanical strength of the scaffolds. The Juglone release behaviours of the scaffolds were examined in vitro conditions.