Hypothalamic obesity in children: pathophysiology to clinical management.

Haliloglu B., BEREKET A.

Journal of pediatric endocrinology & metabolism : JPEM, cilt.28, sa.5-6, ss.503-13, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 5-6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/jpem-2014-0512
  • Dergi Adı: Journal of pediatric endocrinology & metabolism : JPEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.503-13
  • Anahtar Kelimeler: children, craniopharygioma, hypothalamus, obesity, PRADER-WILLI-SYNDROME, INCREASED DAYTIME SLEEPINESS, GASTRIC BYPASS-SURGERY, EARLY-ONSET OBESITY, BODY-MASS INDEX, CHILDHOOD CRANIOPHARYNGIOMA, FOOD-INTAKE, LEPTIN RECEPTOR, ADIPOSE-TISSUE, RISK-FACTORS
  • Marmara Üniversitesi Adresli: Evet

Özet

Hypothalamic obesity (HyOb) is a complex neuroendocrine disorder caused by damage to the hypothalamus, which results in disruption of energy regulation. The key hypothalamic areas of energy regulation are the ARC (arcuate nucleus), the VMH (ventromedial hypothalamus), the PVN (paraventriculer nuclei) and the LHA (lateral hypothalamic area). These pathways can be disrupted mechanically by hypothalamic tumors, neurosurgery, inflammatory disorders, radiotherapy and trauma or functionally as such seen in genetic diseases. Rapid weight gain and severe obesity are the most striking features of HyOb and caused by hyperphagia, reduced basal metabolic rate (BMR) and decreased physical activity. HyOb is usually unresponsive to diet and exercise. Although, GLP-1 and its anologs seem to be a new agent, there is still no curative treatment. Thus, prevention is of prime importance and the clinicians should be alert and vigilant in patients at risk for development of HyOb.