Development of bilayer tissue-engineered scaffolds: combination of 3D printing and electrospinning methodologies

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YILMAZ H., Bedir T., Gursoy S., Kaya E., ŞENEL İ., Tinaz G. B., ...Daha Fazla

Biomedical Materials (Bristol), cilt.19, sa.4, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1088/1748-605x/ad5483
  • Dergi Adı: Biomedical Materials (Bristol)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE, Metadex
  • Anahtar Kelimeler: bilayer scaffold, ciprofloxacin, collagen, gelatin methacryloyl, polycaprolactone, tissue engineering
  • Marmara Üniversitesi Adresli: Evet

Özet

Although different fabrication methods and biomaterials are used in scaffold development, hydrogels and electrospun materials that provide the closest environment to the extracellular matrix have recently attracted considerable interest in tissue engineering applications. However, some of the limitations encountered in the application of these methods alone in scaffold fabrication have increased the tendency to use these methods together. In this study, a bilayer scaffold was developed using 3D-printed gelatin methacryloyl (GelMA) hydrogel containing ciprofloxacin (CIP) and electrospun polycaprolactone (PCL)-collagen (COL) patches. The bilayer scaffolds were characterized in terms of chemical, morphological, mechanical, swelling, and degradation properties; drug release, antibacterial properties, and cytocompatibility of the scaffolds were also studied. In conclusion, bilayer GelMA-CIP/PCL-COL scaffolds, which exhibit sufficient porosity, mechanical strength, and antibacterial properties and also support cell growth, are promising potential substitutes in tissue engineering applications.