Partial virological response to three different nucleotide analogues in naive patients with chronic hepatitis B


Yegin E. G. , ÖZDOĞAN O. C.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, vol.13, no.6, pp.602-611, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1016/s1499-3872(14)60303-9
  • Title of Journal : HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
  • Page Numbers: pp.602-611

Abstract

BACKGROUND: The definition of partial virological response (PVR) was proposed because of its clinical relevance. PVR relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all nucleotide analogues (NA) is not clear. This study was undertaken to analyze PVR influence on therapeutic outcomes during lamivudine, entecavir or tenofovir monotheraphy in NA-naive patients with chronic hepatitis B in routine clinical practice.