Akademik Veri Yönetim Sistemi
Macedonian Journal of Chemistry and Chemical Engineering, cilt.44, sa.1, ss.95-105, 2025 (SCI-Expanded)
Carbamazepine (CBZ) is a widely prescribed antiepileptic and mood stabilizing drug. However, its limited water solubility and low bioavailability challenge its effective use. This study focused on the fabrication and characterization of CBZ-loaded polylactic acid (PLA)/polyethylene glycol (PEG) fibers for controlled drug delivery. The morphology and diameter of the fibers were characterized using scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR) confirmed the successful encapsulation of CBZ within the fibers. Differential scanning calorimetry (DSC) analysis revealed the physical state of the drug in the fiber matrix. As a result of CBZ loading on fibers, the average fiber diameters were measured as ϕ = 1.177 ± 0.238 µm for 10 mg CBZ and ϕ = 1.119 ± 0.248 µm for 50 mg CBZ. It was observed that the increase in electrical conductivity due to an increasing drug concentration, caused a decrease in fiber diameter. When drug release results were analyzed, the fibers showed a controlled release profile extending up to 10 h. These results suggest that the fabricated CBZ-loaded PLA/PEG fibers hold promise as a controlled drug delivery system for CBZ, offering the potential for enhanced therapeutic efficacy, reduced side effects, and improved patient compliance.