The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats


Toklu H. Z. , Kwon O., Sakarya Y., Powers S. K. , Llinas K., Kirichenko N., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.188, ss.510-516, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 188 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2014.01.054
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.510-516

Özet

Background: Mechanical ventilation (MV) is a method of maintaining appropriate gas exchange in patients who are unable to sustain adequate alveolar ventilation. While life-saving in the short-term, prolonged MV leads to altered cardiovascular responses and enhanced lung injury, but the exact mechanism is unknown. Therefore, we investigated the involvement of the sympathoadrenergic and renin-angiotensin system in MV-induced altered cardiovascular responses.