The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats


Toklu H. Z. , Kwon O., Sakarya Y., Powers S. K. , Llinas K., Kirichenko N., ...More

JOURNAL OF SURGICAL RESEARCH, vol.188, no.2, pp.510-516, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 188 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jss.2014.01.054
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.510-516

Abstract

Background: Mechanical ventilation (MV) is a method of maintaining appropriate gas exchange in patients who are unable to sustain adequate alveolar ventilation. While life-saving in the short-term, prolonged MV leads to altered cardiovascular responses and enhanced lung injury, but the exact mechanism is unknown. Therefore, we investigated the involvement of the sympathoadrenergic and renin-angiotensin system in MV-induced altered cardiovascular responses.