The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats

Toklu H. Z., Kwon O., Sakarya Y., Powers S. K., Llinas K., Kirichenko N., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.188, sa.2, ss.510-516, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 188 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2014.01.054
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.510-516
  • Anahtar Kelimeler: Mechanical ventilation, Angiotensin, Losartan, Enalapril, NPY, Thyrosine hydroxylase, Dopamine beta hydroxylase, Sympathetic, Noradrenergic, Norepinephrine, INDUCED LUNG INJURY, RENIN-ANGIOTENSIN SYSTEM, BLOOD-BRAIN-BARRIER, DYSFUNCTION, HUMANS, MODEL, MICE
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background: Mechanical ventilation (MV) is a method of maintaining appropriate gas exchange in patients who are unable to sustain adequate alveolar ventilation. While life-saving in the short-term, prolonged MV leads to altered cardiovascular responses and enhanced lung injury, but the exact mechanism is unknown. Therefore, we investigated the involvement of the sympathoadrenergic and renin-angiotensin system in MV-induced altered cardiovascular responses.