Sex Hormones, Insulin Resistance and High-Density Lipoprotein Cholesterol Levels in Children

Agirbasli M., Agaoglu N. B., Orak N., Caglioz H., Ocek T., Karabag T., ...Daha Fazla

HORMONE RESEARCH IN PAEDIATRICS, cilt.73, sa.3, ss.166-174, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1159/000284357
  • Dergi Adı: HORMONE RESEARCH IN PAEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.166-174
  • Anahtar Kelimeler: Sex hormone-binding globulin, Testosterone, Estradiol, Lipids, Insulin resistance, Children and adolescents, BODY-MASS INDEX, CARDIOVASCULAR RISK, METABOLIC SYNDROME, PHYSICAL-ACTIVITY, BINDING GLOBULIN, TURKISH CHILDREN, PUBERTAL CHANGES, ADOLESCENTS, SENSITIVITY, BOGALUSA
  • Marmara Üniversitesi Adresli: Evet

Özet

Cardiovascular risk starts early in life; therefore, it is of interest to clarify the relation between puberty, sex hormones, insulin resistance and lipid levels in children. This is a cross sectional study of 365 school students (8-18 years of age). We analyzed the associations of sex hormones (testosterone, free androgen index, estradiol, free estradiol index) and sex hormone-binding globulin (SHBG) with insulin resistance and lipid levels. Analyses were performed in prepubertal versus adolescent girls and boys. Among prepubertal boys, estradiol was significantly associated with increased log homeostasis model assessment-estimated insulin resistance (HOMA-IR; B = 0.9, model R(2) = 0.62, p < 0.001) and insulin levels (B = 0.8, model R(2) = 0.58, p < 0.001). Testosterone was associated with increased high-density lipoprotein cholesterol (HDL-C) levels among prepubertal boys (B = 10, model R(2) = 0.42, p = 0.04). Among adolescent girls, SHBG was significantly associated with decreased HOMA-IR (B = -0.8, model R(2) = 0.34, p = 0.01) and insulin levels (B = -0.7, model R(2) = 0.34, p = 0.01). SHBG was also related to increased HDL-C levels among prepubertal (B = 24, model R(2) = 0.42, p = 0.047) and adolescent girls (B = 21, model R(2) = 0.44, p = 0.002). In conclusion, sex hormone levels and SHBG have important effects on HDL-C and insulin resistance among children and adolescents. Copyright (C) 2010 S. Karger AG, Basel