Synthesis and Antimicrobial Activity of Some Novel Schiff Bases Containing 1,2,4-Triazole-3-thione

Calisir M. M., Kocyigit-Kaymakcioglu B., Ozbek B., Otuk G.

E-JOURNAL OF CHEMISTRY, cilt.7, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1155/2010/195725
  • Dergi Adı: E-JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: 1,2,4-Triazole-3-thione, Schiff bases, Antimicrobial activity, MANNICH-BASES, ANTICANCER ACTIVITY, DERIVATIVES, AGENTS, ACID, DESIGN, ANTIBACTERIAL, ANTIFUNGAL, ISATIN
  • Marmara Üniversitesi Adresli: Evet

Özet

A series of Schiff bases (4a-j) were prepared by reacting 4-amino-5-(1-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and substituted aromatic aldehydes. The chemical structures were confirmed by means of UV, (1)H NMR, IR, MS(API-ES) spectral data and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. Among the tested compounds, Schiff bases with 4-OH and 4-NO(2) substituent exhibited remarkable antimicrobial activity against all the tested microorganism.