Nuclear receptor protein: REV-ERB Nükleer reseptör proteini: REV-ERB

Pence M. E.

Northern Clinics of Istanbul, cilt.12, sa.2, ss.258-265, 2025 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.14744/nci.2023.49225
  • Dergi Adı: Northern Clinics of Istanbul
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.258-265
  • Anahtar Kelimeler: Circadian rhythm, nuclear receptors, orphan receptors, REV-ERB α/β
  • Marmara Üniversitesi Adresli: Hayır

Özet

REV-ERB α/β proteins play critical roles in circadian rhythm regulation and are considered to be specialized members of the nuclear receptor family. These so-called “orphan” proteins, whose endogenous ligands were initially unidentified, have become exogenously interferable through synthetic agents with the discovery of their endogenous ligands. This feature has made them an important target for clinical research in recent years. Unlike other nuclear receptors, the unique structure of REV-ERB proteins allows them to perform only transcription inhibition, which makes them even more intriguing. This review summarizes the structural features of REV-ERB α/β proteins and their role in the circadian cycle. We also discuss findings in the literature on the function of REV-ERB α/β proteins in the metabolic and immune systems, emphasizing their importance in these systems.