Male infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects

KOÇ G., Ozdemir A. A., Girgin G., Akbal C., Kirac D., Avcilar T., ...Daha Fazla

INTERNATIONAL JOURNAL OF UROLOGY, cilt.26, sa.2, ss.292-298, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/iju.13863
  • Dergi Adı: INTERNATIONAL JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.292-298
  • Anahtar Kelimeler: array comparative genomic hybridization, infertility, Sertoli cell-only syndrome, DNA METHYLATION, EXPRESSION, PATTERNS, MEIOSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell-only syndrome infertile men. Methods Single-nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell-only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage-gated channel subfamily Q member 1. Conclusions The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell-only syndrome.