Effect of interferon-alpha(2a) on neutrophil adhesion and phagocytosis in chronic myeloid leukemia and Behcet's disease

Karti S., Ovali E., Ratip S., Cetiner M., DİRESKENELİ R. H., Bayik M., ...Daha Fazla

CLINICAL RHEUMATOLOGY, cilt.21, sa.3, ss.211-214, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s10067-002-8288-1
  • Dergi Adı: CLINICAL RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.211-214
  • Anahtar Kelimeler: alpha-interferon, alpha-interferon, Behcet's disease, chronic myeloid leukemia, neutrophil function, CHRONIC MYELOGENOUS LEUKEMIA, ALPHA TREATMENT, INVITRO, LEUKOCYTES, ADHERENCE, GAMMA
  • Marmara Üniversitesi Adresli: Evet

Özet

Alpha-interferon (alpha-IFN) is implicated in a Behcet's disease (BD)-like syndrome observed in a small number of chronic myeloid leukemia (CML) patients. The effect of alpha-IFN on neutrophil adhesion and phagocytosis in CML patients, BD patients and healthy volunteers was investigated to clarify the reason for this observation. Ten subjects were studied for each group by incubating neutrophils with various doses of alpha-IFN. Basal neutrophil adhesions for CML patients, BD patients and healthy volunteers were similar. However, BD patients had greater basal phagocytosis than CML patients, and both groups had greater basal phagocytosis than healthy volunteers. Neutrophil adhesion and phagocytosis of CML patients increased following incubation with higher doses of alpha-IFN, and phagocytosis approached the high levels observed with BD neutrophils. This study provides evidence that alpha-IFN activates neutrophils in CML patients in a dose-dependent manner, and leads to a neutrophil function profile that resembles BD.