Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction


Abueid L., Uslu Ü., Cumbul A., Velioğlu Öğünç A. , Ercan F. , Alican I.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.17, ss.269-275, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2017
  • Doi Numarası: 10.14744/anatoljcardiol.2016.7248
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayıları: ss.269-275

Özet

Objective: The goal of the present study was to investigate the effects of 5-lipoxygenase (5-LOX) inhibition, alone and with cyclooxygenase (COX) inhibitors, on inflammatory parameters and apoptosis in ischemia/reperfusion (I/R)-induced myocardial damage in rats. For this purpose, zileuton, a selective and potent inhibitor of 5-LOX, resulting in suppression leukotriene production, was used.