Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction
ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.17, ss.269-275, 2017 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17
- Basım Tarihi: 2017
- Doi Numarası: 10.14744/anatoljcardiol.2016.7248
- Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.269-275
- Anahtar Kelimeler: cyclooxygenase, ischemia/reperfusion, myocardial infarction, rat, zileuton, 5-lypoxygenase, ISCHEMIA-REPERFUSION INJURY, CEREBRAL-ISCHEMIA, KNOCKOUT MICE, KAPPA-B, PROSTAGLANDIN, ACTIVATION, APOPTOSIS, CYCLOOXYGENASE-2, BIOSYNTHESIS, INFLAMMATION
- Marmara Üniversitesi Adresli: Evet
Özet
Objective: The goal of the present study was to investigate the effects of 5-lipoxygenase (5-LOX) inhibition, alone and with cyclooxygenase (COX) inhibitors, on inflammatory parameters and apoptosis in ischemia/reperfusion (I/R)-induced myocardial damage in rats. For this purpose, zileuton, a selective and potent inhibitor of 5-LOX, resulting in suppression leukotriene production, was used.