Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31

Ozturk A., Nahed B., Bydon M., Bilguvar K., Goksu E., Bademci G., ...Daha Fazla

STROKE, cilt.37, sa.4, ss.1021-1027, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1161/01.str.0000206153.92675.b9
  • Dergi Adı: STROKE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1021-1027
  • Anahtar Kelimeler: aneurysm, genetics, ABDOMINAL AORTIC-ANEURYSMS, GENOME-WIDE LINKAGE, SUBARACHNOID HEMORRHAGE, CEREBRAL ANEURYSMS, CHROMOSOME 19Q13.3, CANDIDATE GENES, FAMILIES, LOCUS, CONFIRMATION, HYPERTENSION
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background and Purpose - Both environmental and genetic factors contribute to the formation, growth, and rupture of intracranial aneurysms (IAs). To search for IA susceptibility genes, we took an outlier approach, using parametric genome-wide linkage analysis in extended IA kindreds in which IA is inherited as a simple Mendelian trait. We hereby present the molecular genetic analysis of 2 such families.